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Analyzing The Effect Of Doxycycline And Gentamicin On Selected Cytosolic Enzymes

BROWSE_DETAIL_CREATION_DATE: 10-08-2018

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BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemical engineering,

BROWSE_DETAIL_CREATORS: Ali, Junaid Mohammed Ali (Author),

BROWSE_DETAIL_CONTRIBUTERS: İşgör, Sultan Belgin (Advisor),

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Doxycycline, Gentamicin, Catalase CAT, Superoxide Dismutase SOD, Glutathione –S–Transferase GST, and Glutathione Peroxidase GPX.


BROWSE_DETAIL_TAB_ABSTRACT

Gentamicin and Doxycycline are antibacterial drugs commonly utilized in a treatment of Gram positive and Gram negative bacterial infections. They have been used in this study to evaluate their effect on antioxidant enzymes such as Catalase (CAT), Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST) and Glutathione Peroxidase (GPX). Each of these drugs are water soluble and shown to be stable when tested in vitro for three months at concentration of 1mg/mL under + 4 ºC and – 20 ºC via UV/VIS spectrophotometer.In this study, several serial dilutions of drug solutions were applied according to enzymatic assay protocols to measure the activities of these enzymes. The comparison of obtained results with the control (zero concentration of drugs) didn’t show any significant effect on each of the enzymes under study. From the observed results, 15% of CAT, 5% of GST activities were inhibited and no effect on GPX and SOD were observed in this study.


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