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Comparative Studies For Synthesis Of Alginate Microspheres And Nanospheres As Drug Carriers

BROWSE_DETAIL_CREATION_DATE: 28-06-2018

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BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemical technology, Chemical engineering,

BROWSE_DETAIL_CREATORS: Alzawi, Hana M. Hamad (Author), İşgör, Sultan Belgin (Author),

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Nanospheres, microspheres, alginate, drug carrier, surfactant, crosslinker.


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The aim of the study is to compare the methods for synthesis of alginate microspheres and nanospheres and get the best size and spherical shape of alginate particles which are used in future as drug delivery. Four groups of methods were done for this purpose, each group of methods was followed the same protocol with some changes. The six methods of the first group were compared between two types of surfactants and also the ratio between alginate and surfactant was compared too. Furthermore, the seven methods of second group were compared in period of stirring time and concentration of alginate, surfactant and crosslinkers. In the third group of study, there are four methods comparing the use of alginate medium viscosity instead of low viscosity and trying to use different type and concentration of crosslinkers (CaCl2 46%, CaCl2 60%, MnCl2 60%, ZnCl2 60%). The final group of our study contains six methods comparing two types of poly vinyl alcohol (low molecular weight and high molecular weight) and different types of crosslinkers (CaCl2 60%,ivMnCl2 60%, ZnCl2 60%). From the twenty three methods were done in our laboratory, the best SEM result was the first method of the fourth group with 5μm in diameter of alginate microspheres that were prepared when using the alginate 1% (low viscosity) with PVA 2% (low molecular weight), AOT 5% and calcium chloride 60%.


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