Bu kaydın yasal hükümlere uygun olmadığını düşünüyorsanız lütfen sayfa sonundaki Hata Bildir bağlantısını takip ederek bildirimde bulununuz. Kayıtlar ilgili üniversite yöneticileri tarafından eklenmektedir. Nadiren de olsa kayıtlarla ilgili hatalar oluşabilmektedir. MİTOS internet üzerindeki herhangi bir ödev sitesi değildir!

Synthesis, Characterization, Electronic Structure and DNA Binding Abilities Of Platinum(LI) Complexes Contining 2,3-DI(2- Thienyl)-Quinoxaline Ligand

BROWSE_DETAIL_CREATION_DATE: 21-03-2018

BROWSE_DETAIL_IDENTIFIER_SECTION

BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemistry,

BROWSE_DETAIL_CREATORS: Fadel, Wadad S. S. (Author),

BROWSE_DETAIL_CONTRIBUTERS: Özalp Yaman, Şeniz (Advisor),

BROWSE_DETAIL_TAB_KEYWORDS

Antitumor drugs, platinum complexes, quinoxalin ligands, DNA bindingability, cytotoxicity.


BROWSE_DETAIL_TAB_ABSTRACT

During the last decades, a number of transition-metal complexes have been utilized toprobe nucleic acid structures and in the development of DNA-cleaving agents. Amongthese complexes platinum(II) ion containing ones are renown. For this purpose, platinumcomplexes of 2,3-di(2-thienyl)-quinoxaline were synthesized in cis, asymmetric and bisgeometry in this work. Identification of the complexes was performed by usingelemental analysis and various spectroscopic techniques.The binding mode and extent of interaction of complexes was determined by UVtitration, thermal decomposition, viscometric and fluorometric measurements.Thermodynamic parameters were also determined from the UV titrations which arerepeatedly carried out at different temperaturesCytotoxicity tests of the complexes werecompleted at neutral medium and IC50 values were calculated for each complex.The DNA binding studies indicated that all the complexes interact with DNA throughgroove binding or electrostatically. Cytotoxicity experiments performed on MDA231IIcell line gave very promising results and revealed that the complex in cis geometry is themost active agent against to breast cancer.Keywords:


BROWSE_DETAIL_TAB_TOC



BROWSE_DETAIL_TAB_DESCRIPTION



BROWSE_DETAIL_TAB_RIGHTS



BROWSE_DETAIL_TAB_NOTES



BROWSE_DETAIL_TAB_REFERENCES


BROWSE_DETAIL_TAB_REFERENCED_BYS

BROWSE_DETAIL_GOTO_LIST

 

TEXT_STATS

  • TEXT_RECORD_STATS
    • TEXT_STATS_THIS_MONTH: 3
    • TEXT_STATS_TOTAL: 2417
  • TEXT_ONLINE_STATS
    • TEXT_ONLINE_STATS_TOTALONLINEVISITOR: 12
    • TEXT_ONLINE_STATS_TOTALONLINEUSER: 0
    • TEXT_STATS_TOTAL: 12

LINK_STATS