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Synthesis, Characterizatıon, Electronic Structure And Dna Binding Abilities Of Platinum(LI) Complexes Containing 2,3- DI(2-Pyrıdyl)-Quinoxaline Ligand

BROWSE_DETAIL_CREATION_DATE: 09-03-2018

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BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemistry,

BROWSE_DETAIL_CREATORS: Hesien, Rehab A. Yaakub (Author),

BROWSE_DETAIL_CONTRIBUTERS: Özalp Yaman, Şeniz (Advisor),

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Antitumor drugs, platinum complexes, quinoxalin ligands, DNA bindingability, cytotoxicity.


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The study on the anticancer efficient metal complexes which have lower toxicity andovercome the resistance of the tumor cells have still been an emerging area andcontinued to be a developing field. Many complexes have been identified with differentbiological behavior having equivalent or higher potential to kill cancerous cells. In thiswork new platinum complexes coordinated to 2,3-di(2-pyridyl)-quinoxaline in cis,asymmetric and bis geometry were synthesized and identified by using spectroscopictechniques.UV titration, thermal decomposition, viscometric and fluorometric measurements wereused to determine the binding ability of the complexes to CT-DNA. Thermodynamicparameters which were from the UV titrations indicated a spontaneous interactionbetween the complexes and the protein. Cytotoxicity tests of the complexes wereperformed on breast cancer MDA231 cell lines at neutral medium and IC50 values werecalculated for each complex.IIGroove binding or electrostatic mode of interaction was suggested for all the complexes.However, no significant cytotoxic effect was obtained in neutral medium for ourcomplexes against breast cancer.


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