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Biochemical Analysis Of Ace Inhibıtors As Commercially Available Antihypertensıve Drugs: Captopril And Lisinopril

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BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemical technology, Chemical engineering,

BROWSE_DETAIL_CREATORS: Albenna, Ahmed Eid Abdelbaset Abdallah (Author),

BROWSE_DETAIL_CONTRIBUTERS: İşgör, Sultan Belgin (Advisor),

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Lisinopril; Captopril; Angiotensin-converting enzyme (ACE) inhibitors; Antioxidant Enzymes, Glutathione-S-Transferase; Catalase; Glutathione Peroxidase; Superoxide Dismutase.


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Angiotensin-converting enzyme (ACE) inhibitors have been under question about their relation with chemotherapeutic drugs resistance or cancer development. There has not been a certain prove about that concern.In our study, we investigate the effect of selected ACE inhibitors drugs on the following enzymes Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Glutathione-S-Transferase (GST), for the first time in the literature. Moreover, the solubility and stability of the drugs were tested with new data revealed about their behavior when stored under certain conditions. Sodium phosphate buffers with pH: 6.5 and pH: 7 were used and the drugs were stored at +4 °C and- 20°C. The drugs were found to be stable for 30 days (the period required to run the enzymatic assays). Captopril showed 98% inhibition for SOD enzyme, 85% inhibition for GST enzyme, only 5% inhibition for CAT enzyme and 11% inhibition for GPx enzyme activities. While Lisinopril showed 99% inhibition for SOD enzyme, 98% inhibition for GST enzyme, 70% inhibition for CAT and 53% inhibition for GPx enzyme activities.


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