Spectroscopic Investıgations On Dna And Bsa Binding Ability Of A New Platinum (Iı) Complex Containing 5,6-Dı(Pyridin-2-Yl)-2,3-Dihydropyrazine Ligand | Atılım University Open Archive System
Bu kaydın yasal hükümlere uygun olmadığını düşünüyorsanız lütfen sayfa sonundaki Hata Bildir bağlantısını takip ederek bildirimde bulununuz. Kayıtlar ilgili üniversite yöneticileri tarafından eklenmektedir. Nadiren de olsa kayıtlarla ilgili hatalar oluşabilmektedir. MİTOS internet üzerindeki herhangi bir ödev sitesi değildir!
Spectroscopic Investıgations On Dna And Bsa Binding Ability Of A New Platinum (Iı) Complex Containing 5,6-Dı(Pyridin-2-Yl)-2,3-Dihydropyrazine Ligand
BROWSE_DETAIL_CREATION_DATE: 09-08-2017
BROWSE_DETAIL_IDENTIFIER_SECTION
BROWSE_DETAIL_TYPE: Thesis
BROWSE_DETAIL_SUB_TYPE: Masters
BROWSE_DETAIL_PUBLISH_STATE: Unpublished
BROWSE_DETAIL_FORMAT: PDF Document
BROWSE_DETAIL_LANG: English
BROWSE_DETAIL_SUBJECTS: Chemical technology, Chemical engineering,
BROWSE_DETAIL_CREATORS: Salem, Asma Mabrouk Mohamed (Author),
BROWSE_DETAIL_CONTRIBUTERS: Özalp Yaman, Şeniz (Advisor),
BROWSE_DETAIL_URL: http://acikarsiv.atilim.edu.tr/browse/2117/
BROWSE_DETAIL_IDENTIFIER_OTHER: http://acikarsiv.atilim.edu.tr/browse/2117/10158353.pdf
BROWSE_DETAIL_TAB_FILE:
BROWSE_DETAIL_SHOW_FILE
BROWSE_DETAIL_SAVE_FILE
Antitumor drugs, platinum complexes, -nitrogen donor ligands, DNA binding ability, BSA binding ability
Designing and synthesis of more effective and less toxic platinum complexes are one of the main aims of the researchers to overcome the side effects of the cisplatinum chemotherapy. For this purpose, a new platinum(II) complex containing 2,3-bis(2-pyridyl)-5,6-dihydropyrazine (PtLCl2) was modelled to mimic the cisplatinum structure , then synthesized and identified by several spectroscopic techniques to assess its DNA and BSA binding ability in this work.In order to elucidate the type of association of the complex to calf thymus DNA, UV titration, fluorometric titration, thermal decomposition and viscometry experiments were conducted under physiological conditions. Thermodynamic parameters were also determined from the UV titrations which are iterated at different temperatures. It is found that PtLCl2 interacts with DNA through groove binding or electrostatically.Binding ability of PtLCl2 to BSA (Bovine Serum Albumin) was also tested with the similar techniques that were used formerly in the DNA association studies. The results clearly indicated that the complex interacted with the hydrophobic region of the protein electrostatically leading an increase in hydrophilicity of the protein.ivThe IR analysis made specifically for identifying the binding side of the complex to BSA were also confirmed increasing in the hydrophilicity of the protein with the effect of PtLCl2.
BROWSE_DETAIL_TAB_REFERENCES
BROWSE_DETAIL_TAB_REFERENCED_BYS