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DNA Interaction And Cytotoxicity Of The Platinum Blue Complex Containing 2-Aminothiophenol

BROWSE_DETAIL_CREATION_DATE: 20-02-2017

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BROWSE_DETAIL_TYPE: Thesis

BROWSE_DETAIL_SUB_TYPE: Masters

BROWSE_DETAIL_PUBLISH_STATE: Unpublished

BROWSE_DETAIL_FORMAT: PDF Document

BROWSE_DETAIL_LANG: English

BROWSE_DETAIL_SUBJECTS: Chemical engineering,

BROWSE_DETAIL_CREATORS: Salem, Safia Mustafa Mahmoud (Author),

BROWSE_DETAIL_CONTRIBUTERS: Özalp Yaman, Şeniz (Advisor),

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Antitumor drugs, platinum blue complexes, DNA binding ability, cytotoxicity


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Since the discovery of cisplatin, metal based agents have gained significant interest of researchers as potential anticancer drugs. Several drugs have been rationally synthesized to overcome the hurdles of cisplatin, majorly its toxicity and resistance. Search for less toxic, but still potent anti-cancer platinum compounds revealed a class of platinum complexes with pyrimidines called platinum-pyrimidine complexes also known as “platinum blue” (Pt-blue) complexes. Here, we describe DNA binding ability of the Pt-blue complex [Pt4(2-atp)8(H2O)(OH)] (2-atp: 2- aminothiophenol).In order to investigate the nature of the interaction between the Pt-blue complex and DNA, spectroscopic measurements were made and the results of UV titration, thermal behavior, viscosity and fluorometric titration of the Pt-blue treated DNA were evaluated. Our results suggested that the compound was able to partially intercalate DNA that related to the anticancer activities of the drugs.


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