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Development Of Graphene Oxide (Go) Modified Electrospun Poly (Ε-Caprolactone) (Pcl) Nanomaterials

Diğer Başlık: Development Of Graphene Oxide (Go) Modified Electrospun Poly (Ε-Caprolactone) (Pcl) Nanomaterials

Oluşturulma Tarihi: 25-09-2019

Niteleme Bilgileri

Tür: Tez

Alt Tür: Yüksek Lisans Tezi

Yayınlanma Durumu: Yayınlanmamış

Dosya Biçimi: PDF

Dil: İngilizce

Konu(lar): Polimerler ve polimer üretimi,

Yazar(lar): Başar, Ahmet Ozan (Yazar),

Emeği Geçen(ler): Türkoğlu Şaşmazel, Hilal (Tez Danışmanı),


Yayın Tarihi: 31-07-2019


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Anahtar Kelimeler

Poly(ε-caprolactone); Graphene oxide; Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP); Thiophene (Th); Scaffold


Özet

The aim of this study was to fabricate 3D, composite tissue scaffolds with synthetic biodegradable polymer poly(ε-caprolactone) (PCL) and graphene oxide (GO) combined together by using electrospinning technique. Additionally, the effect of Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) and/or thiophene (Th) modified GO on the composite PCL/GO mats (PCL/GO, PCL/GO-GRGDSP, PCL/GO-Th, PCL/GOGRGDSP-Th) was further studied. Characterizations of the powder GO-based samples were carried out by ATR-FTIR and Raman analyses. Characterizations of the scaffolds were performed by thickness measurements, Scanning Electron Microscopy (SEM), contact angle (CA) measurements, X-ray photoelectron spectroscopy (XPS), thermogravimetric analyses (TGA), electrical conductivity tests, PBS absorption and shrinkage tests, in vitro degradation and mechanical tests. According to SEM micrographs, all of the scaffolds were exhibited bead-free and uniform morphology. Better hydrophilicity and a light CA decrease (~5°) for PCL/GO scaffolds were observed with the addition of GO. The enhanced electrical conductivity was observed with the incorporation of PCL and GO and the highest conductivity value was measured for PCL/GO-GRGDSP-Th (2%) as 15.06 μS.cm-1. Mechanical properties of the scaffolds were improved with the well-dispersion and addition of GO in PCL matrix. Additionally, cell-material interactions were studied with MG-63 osteoblast cell line with MTT assay, ALP activitiy, Alizarin-Red staining, fluorescence and SEM analyses. Cell culture studies showed that PCL/GOGRGDSP-Th (0.5%) scaffolds exhibited highest biocompatibility performance at least 1.87 fold in MTT absorbance value compared to neat PCL scaffolds due to the advanced properties of GO and the biological interfaces. 


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