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The Biochemical Evaluation Of Tylosıin And Enrofloxacin On Selected Enzymes

Oluşturulma Tarihi: 16-08-2018

Niteleme Bilgileri

Tür: Tez

Alt Tür: Yüksek Lisans Tezi

Yayınlanma Durumu: Yayınlanmamış

Dosya Biçimi: PDF

Dil: İngilizce

Konu(lar): Kimya, Biyoloji (Genel),

Yazar(lar): Alatrash, Taher Mehemed A. (Yazar),

Emeği Geçen(ler): İşgör, Sultan Belgin (Danışman),

Anahtar Kelimeler

Enrofloxacin Enr, Tylosin Tyl, Glutathione Peroxidase GPX, Superoxide Dismutase SOD, Glutathione S Transferase GST and Catalase CAT


Özet

The antibiotics Enrofloxacin and Tylosin were used widely in the veterinary field due to its effectiveness against Gram positive and Gram negative bacteria. However, they can also be the reason of several negative effects such as the inhibition of antioxidant enzymes activities, for example Catalase (CAT), Superoxide Dismutase (SOD), Glutathione S Transferase (GST) and Glutathione Peroxidase (GPX) which may lead to an oxidative stress in the body. This study was conducted to evaluate the effects of two antibiotics on these enzymes. Enrofloxacin was dissolved in DMSO, whereas Tylosin was dissolved in water at a concentration 1mg/ml for both drugs. The stability measured by UV absorbance at 276 nm for Enrofloxacin and at 282 nm for Tylosin showed that both drugs were stable in dark environment at +4°C and at room temperature for three months. The enzyme assays with serial concentration of drugs resulted that Enrofloxacin decreased the activity of CAT and GST by 10% and 5% respectively, while increased GPX activity by 15%. There were no change in CAT and GST activities with Tylosin, hovewer, 10% increase of GPX activity was observed. The results showed that Enrofloxacin and Tylosin may not cause an oxidative stress in the body, and hence Enrofloxacin and Tylosin can be suggested to use safely among with other antibiotics that may have adverse effects on the antioxidant enzymes. 


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