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Comparative Studies For Synthesis Of Alginate Microspheres And Nanospheres As Drug Carriers

Oluşturulma Tarihi: 28-06-2018

Niteleme Bilgileri

Tür: Tez

Alt Tür: Yüksek Lisans Tezi

Yayınlanma Durumu: Yayınlanmamış

Dosya Biçimi: PDF

Dil: İngilizce

Konu(lar): Kimyasal teknoloji, Kimya mühendisliği,

Yazar(lar): Alzawi, Hana M. Hamad (Yazar), İşgör, Sultan Belgin (Yazar),

Emeği Geçen(ler):

Anahtar Kelimeler

Nanospheres, microspheres, alginate, drug carrier, surfactant, crosslinker.


Özet

The aim of the study is to compare the methods for synthesis of alginate microspheres and nanospheres and get the best size and spherical shape of alginate particles which are used in future as drug delivery. Four groups of methods were done for this purpose, each group of methods was followed the same protocol with some changes. The six methods of the first group were compared between two types of surfactants and also the ratio between alginate and surfactant was compared too. Furthermore, the seven methods of second group were compared in period of stirring time and concentration of alginate, surfactant and crosslinkers. In the third group of study, there are four methods comparing the use of alginate medium viscosity instead of low viscosity and trying to use different type and concentration of crosslinkers (CaCl2 46%, CaCl2 60%, MnCl2 60%, ZnCl2 60%). The final group of our study contains six methods comparing two types of poly vinyl alcohol (low molecular weight and high molecular weight) and different types of crosslinkers (CaCl2 60%,ivMnCl2 60%, ZnCl2 60%). From the twenty three methods were done in our laboratory, the best SEM result was the first method of the fourth group with 5μm in diameter of alginate microspheres that were prepared when using the alginate 1% (low viscosity) with PVA 2% (low molecular weight), AOT 5% and calcium chloride 60%.


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Sosyal Medya ve Araçlar

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