Synthesis, Characterizatıon, Electronic Structure And Dna Binding Abilities Of Platinum(LI) Complexes Containing 2,3- DI(2-Pyrıdyl)-Quinoxaline Ligand | Atılım Üniversitesi Açık Erişim Sistemi
Bu kaydın yasal hükümlere uygun olmadığını düşünüyorsanız lütfen sayfa sonundaki Hata Bildir bağlantısını takip ederek bildirimde bulununuz. Kayıtlar ilgili üniversite yöneticileri tarafından eklenmektedir. Nadiren de olsa kayıtlarla ilgili hatalar oluşabilmektedir. MİTOS internet üzerindeki herhangi bir ödev sitesi değildir!
Synthesis, Characterizatıon, Electronic Structure And Dna Binding Abilities Of Platinum(LI) Complexes Containing 2,3- DI(2-Pyrıdyl)-Quinoxaline Ligand
Oluşturulma Tarihi: 09-03-2018
Niteleme Bilgileri
Tür: Tez
Alt Tür: Yüksek Lisans Tezi
Yayınlanma Durumu: Yayınlanmamış
Dosya Biçimi: PDF
Dil: İngilizce
Konu(lar): Kimya,
Yazar(lar): Hesien, Rehab A. Yaakub (Yazar),
Emeği Geçen(ler): Özalp Yaman, Şeniz (Danışman),
URL: http://acikarsiv.atilim.edu.tr/browse/2216/
Diğer Niteleme Bilgileri: http://acikarsiv.atilim.edu.tr/browse/2216/10183210.pdf
Antitumor drugs, platinum complexes, quinoxalin ligands, DNA bindingability, cytotoxicity.
The study on the anticancer efficient metal complexes which have lower toxicity andovercome the resistance of the tumor cells have still been an emerging area andcontinued to be a developing field. Many complexes have been identified with differentbiological behavior having equivalent or higher potential to kill cancerous cells. In thiswork new platinum complexes coordinated to 2,3-di(2-pyridyl)-quinoxaline in cis,asymmetric and bis geometry were synthesized and identified by using spectroscopictechniques.UV titration, thermal decomposition, viscometric and fluorometric measurements wereused to determine the binding ability of the complexes to CT-DNA. Thermodynamicparameters which were from the UV titrations indicated a spontaneous interactionbetween the complexes and the protein. Cytotoxicity tests of the complexes wereperformed on breast cancer MDA231 cell lines at neutral medium and IC50 values werecalculated for each complex.IIGroove binding or electrostatic mode of interaction was suggested for all the complexes.However, no significant cytotoxic effect was obtained in neutral medium for ourcomplexes against breast cancer.
Kaynakça
Atıf Yapanlar